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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically focused on the practical aspects of study design, including the recruitment process and consent in adherence, as well as the use of standard equipment.

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for a pragmatic trial to be reliable and to reduce bias in the results, is also necessary. However, too much heterogeneity can result in problems with the trial design.

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The goal of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually commissioned by policymakers and practitioners in order to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. They should, however, not, be used to replace the need for 프라그마틱 환수율 정품 (Https://Xlabs.Ru:443/Bitrix/Redirect.Php?Goto=Https://Pragmatickr.Com/) explanation studies.

The pragmatism concept is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study which includes recruitment, design, implementation of the intervention and its follow-up.

There is a growing trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatics. However, it is important to remember that the majority of these trials were conducted in primary care settings.